This film is about Pauline, a young woman (18yo) who lives with her family and her younger sister Grace who has Cystic Fibrosis. Pauline has some delusions of being a great surgeon, and she also has some horrific dreams that she actually finds "stimulating" to say the least. Her family put up with her delusions and her school classmates find her annoying. But as this is all happening around her she has a plan, a plan that will leave them all shocked, and some people may not survive.

William has cystic fibrosis and is struggling to live life to the fullest, choosing to spend his time shopping for coffins. After his friend Bobby dies, William finds himself in a lawyer's office trying to understand the ludicrous conditions Bobby put in his will. William is committed to driving Bobby's ashes to a healing shrine in Mexico. Along for the ride is Bobby's sister Hannah and a home-built car unlikely to go the distance. William and Hannah form a relationship along the Pacific Highway as William struggles with his declining health and the pair fight the obstacles in the path to a miracle.

In Manhattan, the successful executive Jack is a methodical and controlled man with simple habits that works in an advertisement agency with his coworker George. While smoking a cigarette on the roof of the building of the agency, Jack meets the aspirant actress Jill that has just arrived in New York and is seeking a job. He sympathizes with her situation and gives her name to a Klubendorf commercial in the campaign promoted by his agency. When he takes Jill home, he finds that she lives in a very low-budget hotel and out of the blue, he invites her to stay in the guest room of his fancy apartment for a while. Jill changes the behavior of Jack that becomes happier, and proposes Jack to write together a manifesto where the first rule is "be honest". However, she omits to Jack that she is sick with cystic fibrosis and she would have only a couple of years more. When Jack discovers that Jill is ill...